Apply a small amount to face in the PM as part of your skincare regimen, after water-based serums but before heavier treatments. Do not use with other retinoid treatments. Avoid unprotected solar exposure. Caution: Retinol can cause irritation, redness and peeling, especially around the eyes and mouth, in the early stages of treatment while skin builds tolerance. If persistent irritation occurs, cease use and consult a physician. Use only as directed on unbroken skin.